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KMID : 0191120100250071066
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Journal of Korean Medical Science
2010 Volume.25 No. 7 p.1066 ~ p.1070
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Epithelial-Mesenchymal Transitions of Bile Duct Epithelial Cells in Primary Hepatolithiasis
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Zhao Li-Jin
Yang Ri-Gao
Cheng Long
Wang Mai-Jian
Jiang Yan
Wang Shu-Guang
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Abstract
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The purpose of this study was to explore the role of epithelial-mesenchymal transition in the pathogenesis of hepatolithiasis. Thirty-one patients with primary hepatolithiasis were enrolled in this study. Expressions of E-cadherin, α-catenin, α-SMA, vimentin, S100A4, TGF-β1 and P-smad2/3 in hepatolithiasis bile duct epithelial cells were examined by immunohistochemistry staining. The results showed that the expressions of the epithelial markers E-cadherin and α-catenin were frequently lost in hepatolithiasis (32.3% and 25.9% of cases, respectively), while the mesenchymal markers vimentin, α-SMA and S100A4 were found to be present in hepatolithiasis (35.5%, 29.0%, and 32.3% of cases, respectively). The increased mesenchymal marker expression was correlated with decreased epithelial marker expression. The expressions of TGF-β1 and P-smad2/3 in hepatolithiasis were correlated with the expression of S100A4. These data indicate that TGF-β1-mediated epithelial-mesenchymal transition might be involved in the formation of hepatolithiasis.
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KEYWORD
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Epithelial-mesenchymal Transition, Primary Hepatolithiasis, Bile Duct Epithelial Cell, Transforming Growth Factor beta1, Immunohistochemistry
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